Subject: RE:
From: "Yung,W K Alfred" <[email-masked]>
To: "'Hallie Biden'" <[email-masked]>
Cc: "Beau Biden" <[email-masked]>, <[email-masked]>
Date: Thu, 18 Dec 2014 20:24:04 +0000

Hallie,
AS I mentioned on the phone. I am not impressed with the new area of enhancement seen in yesterday’s scan, I think it a necrosis area. As to the question of a drug holiday so to see if Beau will get stronger without so much treatment. I think it is too risky to stop both drugs, and my intention is really to use the anti-PD-1 antibodies (Pembrolizumab) with Avastin when we take away CCNU. It will be OK to give Beau a few weeks of break from CCNU to see how the weakness will go. I like him to continue with the Avastin, get the dose tomorrow, and we can touch base again after the New Year and to decide on what to do with CCNU.
Al

W.K. Alfred Yung, M.D.
Chairman, Department of Neuro-Oncology
Margaret and Ben Love Chair in Clinical Cancer Care
UT M. D. Anderson Cancer Center, Unit 431
1515 Holcombe Blvd
Houston, TX 77030
Tele:  713-794-1285
Fax:  713-563-0151
[email-masked]

From: Hallie Biden [mailto:[email-masked]]
Sent: Thursday, December 18, 2014 12:21 PM
To: Yung,W K Alfred
Subject:

Hi Al,
Once you have connected with Jon Glass regarding the last scan, please let me know your thoughts. He sounded a little concerned about the latest necrosis that developed. Should Beau get the avastin tomorrow as scheduled? Do you think moving away from the avastin could be helpful?
Let me know your thoughts when you get a chance,
thanks,
Hallie

--
Hallie Olivere Biden