Subject: DemerX
From: <[email-masked]>
To: "Hunter Biden" <[email-masked]>
Date: Fri, 14 Aug 2015 04:52:51 -0700

Dear Hunter;

I thought the celebration of Beau's life was extremely moving and very powerful. I thought the whole Biden Family really demonstrated what it is like to have a close family and how a family can endure the unthinkable and put your best foot forward in order to conquer the coming days ahead.

I met Beau at our non-obvious dinner 4 years ago at the Wilmington Club. He was talking about the dangers of Face-book and Crime and I was doing my addiction pitch. "Healing addiction without causing addiction". Beau came up to me at the end of the dinner and asked if I was related to a Matthew Mellon. I said yes he was my brother. We immediately hit it off as he recounted some crazy stories back from the Penn days that he remembered about my brother. I can honestly say I didn't know Beau well but as you mentioned in your Eulogy I think Beau offered a comfort to so many people that they all thought they knew him well. I just knew that I liked him from the very first 5 minutes we chatted and always just admired him with all our conversations. I would just like to say your remembrances of Beau's past really resonated with my memories of Beau so it was extremely moving.

I told you I would keep you in the loop on addiction trials. So I just copied you on the latest. We had great success on patient 1 who was an Oxycontin addict for 14 years. She is now clean for 3 months.

Below I have copied you on the Dr. Lams notes. This patient has been using since he was 16. Currently 42 years of age and has been using Heroin on a daily basis for years! So as you can gather from the notes this is a big change for this patient. To just sum things up this molecule appears to some how go right to the source of cravings and have a profound impact as you can read below!

I just wanted to follow up on my end to give you the latest in DemerX. I am in Maine till the 24th but if you would like to hear more about whats going on with our future patients just let me know. If you are over at your Dads send me a text and I am happy to get together and catch up. Just know the Mellons have the Biden Family in our thoughts and Prayers!

Hoping you are having some quality family time this Summer! All the Best! Henry

Henry Mellon

MELLON GROUP LLC

Hi Team,

I attach below the discharge interview note with subject 9019, which consists mainly of verbatim quotes from the subject:

________________________________________

“It's kind of a miracle. I don’t use that term very often.”

“It’s not very often that things go above and beyond expectations in my life and it did. And that’s from a hard-core lifetime junkie. It’s frigging wild.”

“The actual success, is incredible. Full stop. Magic pill.”

When asked about sleep disruption, replied, “If you screw up your sleep cycle for a little while, and to not be a junkie anymore, I’ll take it. I would do it again standing on my head.”

“It’s brought back some memories that I haven’t thought about for awhile, and I remember them as they were, but how I’m thinking about them is more positive.”

When talking about his recollections of a failed romance, “The interpretation is not just that she was a crazy alcoholic bitch, but also that I was nuts to be there and let this kind of thing happen and put myself in the situation. It’s kind of like being able to take some of the blame, and some of the responsibility for the situation. It’s kind of the ego dropping a bit.”

“I had lots of regret and resentment, and that’s gone down. It’s like defragging a computer, or sending data to off-site storage. It feels like the future is a series of new days, and the possibilities are out there.”

“It’s not like an artificial happy pill, and lala this is great. It’s about how the world is affecting me, and how it’s not affecting me. It’s recalibrating. It’s about what’s going to bother me, and what’s not going to bother me. The stuff in the past is not going to hinder my decisions. The world seems like it has much more possibilities.”

“I wanted to be happy and sober at the same time, which I am now, which is something that never happens to me.”

________________________________________

A more

Regards,

Dr. Lam

Holger Weis

President, Chief Operating Officer &

Chief Financial Officer

305 S. Andrews Avenue, Suite 515

Fort Lauderdale, FL 33301  USA

Main:   954.607.3670

Direct: 954.607.3673

Fax:   954.607.3678

Mobile:  561.306.0343

Email:   [email-masked]

Confidentiality Notice: Unless otherwise clearly indicated, this communication may contain confidential or proprietary information of DemeRx, Inc. that is intended only for the use of the individual or entity named above and that may not be further disclosed.   If the reader of this transmission is not the intended recipient, or the employee or agent responsible for delivering this communication to the intended recipient, you are hereby notified that any dissemination, distribution or copying of this communication is strictly prohibited. If you have received this communication in error, please notify us immediately by replying to this message and destroy any copies, electronic, paper or otherwise, which you may have of this communication. Thank you.

From:  Holger Weis
Sent:  Tuesday, August 04, 2015 5:18 PM
To:  Henry Mellon
Subject:  Re: DMX 100/ 1005862: Day 5 AM Update [Subject 02-003]

As an addendum to yesterday's notes, we just received the following note from Dr Lam:

As a small addendum, which is captured in the source and paraphrased here,  subject 9019 has continued to have observations similar to yesterday’s, which illustrate his shift in perspective. For instance, while outside smoking a cigarette yesterday evening, he witnessed what he recognized to be a probable ‘drug deal’, some distance away on the sidewalk. Late last night, he heard fireworks being set off from a nearby balcony. In both instances, he recognized that these occurrences normally would have provoked very negative reactions in him, but he was able to observe them with a sense of detachment and acceptance. He also finds himself thinking a great deal about the future, and about plans for the future with respect to housing and work.

Holger Weis

(561) 306-0343

Sent from my iPhone

On Aug 3, 2015, at 4:29 PM, Holger Weis <[email-masked]> wrote:

Henry,

CONFIDENTIAL UPDATE see note from Dr. Lam’s note below.  I don’t have an update since this note.  Today is a holiday in Ontario so this may be the reason they have not provided us with an update.

For your information, to put Dr. Lam’s timepoints of his notes into perspective from when treatment was started:

02AUG 10:36 was hour  96  after starting treatment

“yesterday around midday” which appears to be the time when subject turned the corner approximated hour  76  after starting treatment

02 AUG 15:30 was hour  102  after starting treatment

02 AUG 16:19 was hour  102  after starting treatment

As I mentioned, the first subject is now 83 days free of opiates and continues to do very well.

Holger Weis

President, Chief Operating Officer &

Chief Financial Officer

305 S. Andrews Avenue, Suite 515

Fort Lauderdale, FL 33301  USA

Main:   954.607.3670

Direct: 954.607.3673

Fax:   954.607.3678

Mobile:  561.306.0343

Email:   [email-masked]

Confidentiality Notice: Unless otherwise clearly indicated, this communication may contain confidential or proprietary information of DemeRx, Inc. that is intended only for the use of the individual or entity named above and that may not be further disclosed.   If the reader of this transmission is not the intended recipient, or the employee or agent responsible for delivering this communication to the intended recipient, you are hereby notified that any dissemination, distribution or copying of this communication is strictly prohibited. If you have received this communication in error, please notify us immediately by replying to this message and destroy any copies, electronic, paper or otherwise, which you may have of this communication. Thank you.

From:  Lam, Vincent [mailto:[email-masked]]
Sent:  Sunday, August 02, 2015 4:42 PM
To:  Sivanesan, Sinthujaa; Holger Weis; Nagham Nazhat; Roland Gerritsen van der Hoop
Cc:  Thompson, Halima; Aghamanoukian, Tamar; Geoffroy, Pierre; Charles, Mercy; Szeto, Isabella
Subject:  Re: DMX 100/ 1005862: Day 5 AM Update [Subject 02-003]

Hi All,

Thanks very much Sinthu for the update.

I would just like to share with you three recent contact notes, which document observations that I found very interesting. I have opened a corresponding AE, “Increased sense of optimism”. The three contact notes are reproduced verbatim below.

02 August – 10:36

Subject tells me that he has had a shift in perspective which he describes as “miraculous”. He tells me his normal thought patterns focus on the ills of the world and his inability to change them. He says that this normally colors his mood and outlook such that he has an overall sense of hopelessness about the future. However, yesterday around midday, the subject became aware that his thoughts were much more positive. He says that he began to think of things he would like to do, which are positive, such as contacting old friends and family members on social media, from whom he has been estranged for 6 years. Subject, when asked, stated that since his teen years, he has not felt a sense of optimism in the absence of substance use. He has felt optimistic during intoxication, but never during sobriety since he was a teenager. He then described all previous times of sobriety as “a miserable existence”, and he finds it quite remarkable that he has a sense of optimism in the present circumstances. He has posted his phone number on Facebook, and says with a shrug and sense of equanimity, “some people in my life probably want to kill me, but I should just let is happen and move on.” Subject says, “You just might turn out to be the saviour of my life.” Subject told that if anything, he will play that role himself, but we are pleased at his outlook.

02 August – 15:30

I spoke with the subject, while walking, for about an hour. I inquired about the increased sense of optimism. Subject feels this is ongoing, and is very distinct in saying that it is not an euphoric experience at all; it is a shift in perspective. As example, subject pointed out a garbage collection practice which he witnessed, which he feels is inefficient and involves what he feels is a deception of the public regarding the nature of recycling programs. Subject indicated that normally, this would be sufficient to ruin his day, that he would likely have confronted the garbage collector about this particular practice, that his mood would have been soured by the incident, he would have felt it necessary to use opioids in order to improve his mood, and all of these consequences would have been typical and unavoidable. Another example subject pointed out is that he does not feel negative talking about his experiences with drugs, which normally he would. He feels a sense that he is more open and might like to attend group therapy types of activities, which are normally unappealing to him because the discussion of drug use gives him negative thoughts. Now he feels he would be receptive both to sharing and listening.

02 August – 16:19

Per subject request, I have notified our contracted counsellor that the subject would be receptive to speaking with her whenever she is available. An addendum to previous: during our discussion of the garbage collector, I inquired about the normal reaction processes the subject would have to seeing something which bothers him – specifically whether he normally reacted without thinking, or whether he felt that he had a choice with respect to his reactions. This query resonated with the subject, who indicated that now he felt an acceptance that garbage collection practices might not be optimal, but that this was not something he could necessarily change, and was not something he was obliged to be upset about, as his normal reaction would be; but rather was something he could disagree with while moving on in his own life. I gave the subject a book on mindfulness, which the counsellor had left for the other subject (who is not making use of it).

1105 Market Street

Suite 1800

Wilmington, Delaware 19801

302.351.8291 - work

302.351.4942 - fax

561.302.4699 - cell

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